Use of levosimendan in acute and advanced heart failure: short review on available real-world data

Use of levosimendan in acute and advanced heart failure: short review on available real-world data

Blog Article

Eugene Pashkovetsky, Chhaya Aggarwal Gupta, Wilbert S AronowDivision of Cardiology, Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USAAbstract: Published data have shown potential advantages of levosimendan in the management of acute decompensated heart failure and advanced Ski de fond - Enfant - Bottes heart failure when standard medical therapies threaten hemodynamics and organ perfusion are unable to alleviate clinical symptoms.Levosimendan distinguishes itself from other catecholaminergic inotropes by its three mechanisms of action: positive inotropy, vasodilation, and cardioprotection.In addition, its pharmacokinetics allow for a longer duration of action from the Dryer Blower Belt metabolite OR1896 allowing for further cardiovascular therapeutic effects for several days, even after discontinuation of the parent drug.Keywords: levosimendan, heart failure, inotropic therapy.